LILRA6 copy number variation correlates with susceptibility to atopic dermatitis
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Published version
Author(s)
Type
Journal Article
Abstract
Leukocyte immunoglobulin-like receptors (LILR) are expressed mostly on myelomonocytic cells where they are mediators of immunological tolerance. Two LILR genes, LILRA3 and LILRA6, exhibit marked copy number variation. We assessed the contribution of these genes to atopic dermatitis (AD) by analysing transmission in 378 AD families. The data indicated that copies of LILRA6 were over-transmitted to affected patients. They are consistent with a contribution of LILR genes to AD. They could affect the equilibrium between activating and inhibitory signals in the immune response.
Date Issued
2016-06-22
Date Acceptance
2016-06-10
Citation
Immunogenetics, 2016, 68 (9), pp.743-747
ISSN
1432-1211
Publisher
Springer Verlag
Start Page
743
End Page
747
Journal / Book Title
Immunogenetics
Volume
68
Issue
9
Copyright Statement
© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
License URL
Subjects
AD
Atopic dermatitis
CNV
LILR
Immunology
1107 Immunology
Publication Status
Published