No association of alcohol use and the risk of ulcerative colitis or Crohn's disease: data from a European Prospective cohort study (EPIC).
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Background
The role of long
-term alcohol consumption for the risk of developing ulcerative colitis
(UC)
and
Crohn’s disease (CD)
is unclear.
Aim
s
For the first time, t
o prospectively assess the role of pre
-disease alcohol consumption o
n
the risk of developing UC or CD.
Methods
Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC
-
IBD
), incident UC and CD cases and ma
tched controls where included. At recruitment,
participants
completed
validated food frequency and lifestyle questionnaires. Alcohol
consumption was classified as
either:
non
-use, former, light (
≤
0.5
and 1 drink/week),
below the recommended limits (BRL) (
≤
1 and 2 drinks/day), moderate (
≤
2.5 and 5
drinks/day)
, or
heavy use (>2.5 and >5 drinks/ day) for women and men, respectively
; and
was expressed as
consumption
at enrolment and during
lifetime. Conditional logistic
regression was applied adjusting for smoking
and
education
, taking light users as the 3
Abstract
Background
The role of long
-term alcohol consumption for the risk of developing ulcerative colitis
(UC)
and
Crohn’s disease (CD)
is unclear.
Aim
s
For the first time, t
o prospectively assess the role of pre
-disease alcohol consumption o
n
the risk of developing UC or CD.
Methods
Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC
-
IBD
), incident UC and CD cases and ma
tched controls where included. At recruitment,
participants
completed
validated food frequency and lifestyle questionnaires. Alcohol
consumption was classified as
either:
non
-use, former, light (
≤
0.5
and 1 drink/week),
below the recommended limits (BRL) (
≤
1 and 2 drinks/day), moderate (
≤
2.5 and 5
drinks/day)
, or
heavy use (>2.5 and >5 drinks/ day) for women and men, respectively
; and
was expressed as
consumption
at enrolment and during
lifetime. Conditional logistic
regression was applied adjusting for smoking
and
education
, taking light users as the
reference.
Results
Out of 262,451
participants
in
6 countries, 198 UC incident cases/792 controls and 84 CD
cases/336 controls were included. At enrolment,
8%/27%/3
2%/2
3%/1
1% UC
cases
and
7%/2
9%/4
0%/19%/
5% C
D cases
were:
non
-users, light, BRL, moderate and heavy users,
respectively.
The corresponding figures for
lifetime
non
-use, former, light, BRL, moderate
and heavy use
were
: 3%/5%/2
3%/44%/19%/6% and
5%/2%/25%/44%/23
%/1% for UC
and CD cases
, respectively. There were no associations between any categories of alcohol
consumption and risk of UC or CD
in the una
djusted and adjusted odds ratios
.
Conclusion
There was no evidence of association
s between
alcohol
use
and the odds of
developing
either UC or CD
.
The role of long
-term alcohol consumption for the risk of developing ulcerative colitis
(UC)
and
Crohn’s disease (CD)
is unclear.
Aim
s
For the first time, t
o prospectively assess the role of pre
-disease alcohol consumption o
n
the risk of developing UC or CD.
Methods
Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC
-
IBD
), incident UC and CD cases and ma
tched controls where included. At recruitment,
participants
completed
validated food frequency and lifestyle questionnaires. Alcohol
consumption was classified as
either:
non
-use, former, light (
≤
0.5
and 1 drink/week),
below the recommended limits (BRL) (
≤
1 and 2 drinks/day), moderate (
≤
2.5 and 5
drinks/day)
, or
heavy use (>2.5 and >5 drinks/ day) for women and men, respectively
; and
was expressed as
consumption
at enrolment and during
lifetime. Conditional logistic
regression was applied adjusting for smoking
and
education
, taking light users as the 3
Abstract
Background
The role of long
-term alcohol consumption for the risk of developing ulcerative colitis
(UC)
and
Crohn’s disease (CD)
is unclear.
Aim
s
For the first time, t
o prospectively assess the role of pre
-disease alcohol consumption o
n
the risk of developing UC or CD.
Methods
Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC
-
IBD
), incident UC and CD cases and ma
tched controls where included. At recruitment,
participants
completed
validated food frequency and lifestyle questionnaires. Alcohol
consumption was classified as
either:
non
-use, former, light (
≤
0.5
and 1 drink/week),
below the recommended limits (BRL) (
≤
1 and 2 drinks/day), moderate (
≤
2.5 and 5
drinks/day)
, or
heavy use (>2.5 and >5 drinks/ day) for women and men, respectively
; and
was expressed as
consumption
at enrolment and during
lifetime. Conditional logistic
regression was applied adjusting for smoking
and
education
, taking light users as the
reference.
Results
Out of 262,451
participants
in
6 countries, 198 UC incident cases/792 controls and 84 CD
cases/336 controls were included. At enrolment,
8%/27%/3
2%/2
3%/1
1% UC
cases
and
7%/2
9%/4
0%/19%/
5% C
D cases
were:
non
-users, light, BRL, moderate and heavy users,
respectively.
The corresponding figures for
lifetime
non
-use, former, light, BRL, moderate
and heavy use
were
: 3%/5%/2
3%/44%/19%/6% and
5%/2%/25%/44%/23
%/1% for UC
and CD cases
, respectively. There were no associations between any categories of alcohol
consumption and risk of UC or CD
in the una
djusted and adjusted odds ratios
.
Conclusion
There was no evidence of association
s between
alcohol
use
and the odds of
developing
either UC or CD
.
Date Issued
2017-01-25
Date Acceptance
2016-12-05
Citation
European Journal of Clinical Nutrition, 2017, 71, pp.512-518
ISSN
1476-5640
Publisher
Nature Publishing Group
Start Page
512
End Page
518
Journal / Book Title
European Journal of Clinical Nutrition
Volume
71
Copyright Statement
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Sponsor
Imperial College Trust
Grant Number
P47328
Subjects
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
INFLAMMATORY-BOWEL-DISEASE
ALL-CAUSE MORTALITY
ENVIRONMENTAL-FACTORS
REDUCED MORTALITY
WINE CONSUMPTION
LIFE-STYLE
POPULATION
NUTRITION
DIET
SMOKING
1111 Nutrition And Dietetics
1106 Human Movement And Sports Science
0908 Food Sciences
Publication Status
Published