Knowledge-based immune-therapeutic advances for transplantation and cancer
File(s)
Published version
Author(s)
Simpson, Elizabeth
Type
Journal Article
Abstract
Increased knowledge about immune responses to what is perceived as ‘foreign’ or ‘non-self’ has revealed extraordinary levels of complexity. Research uncovering these has the potential to optimise immunotherapy. Remarkable progress has been made in transplantation leading to much less acute rejection and a very significant increase in long-term survival. These and other beneficial results have been achieved by stepwise advances, using combinations of less toxic chemotherapies with biological immunosuppressive agents alongside innovatory surgical skills. However, rejection is the default pathway for entities deemed ‘foreign’, including mistaken suspects like autoantigens. For tumour immunotherapy the identification of bona fide tumour antigens recognised by B and/or T cell receptors has mushroomed but has yet to be optimised to take into account mutations leading to tumour evasion. We are now at the beginning of a road that looks more hopeful by being informed of the complexities. Basic and translational research between the late 1960s and now have yielded an extraordinarily rich harvest of new knowledge. More is to come, further insight is needed and new paradigms explored.
Date Issued
2025-03-28
Date Acceptance
2025-03-26
Citation
Immunotherapy Advances, 2025, 5 (1)
ISSN
2732-4303
Publisher
Oxford University Press
Journal / Book Title
Immunotherapy Advances
Volume
5
Issue
1
Copyright Statement
© The Author(s) 2025. Published by Oxford University Press on behalf of the British Society for Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40606651
PII: ltaf014
Subjects
ANTIBODY
ANTIGEN
cancer immunology
COMPLEX
GENES
IDENTIFICATION
Immunology
Life Sciences & Biomedicine
MOUSE Y-CHROMOSOME
REGION
retrospective
Science & Technology
T-CELLS
TOLERANCE
transplantation immunology
Publication Status
Published
Coverage Spatial
England
Article Number
ltaf014
Date Publish Online
2025-03-28