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Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells
File(s)
CECA-S-20-00141.pdf (2.11 MB)
Accepted version
Author(s)
Georgiadou, Eleni
Rutter, Guy A
Type
Journal Article
Abstract
Mitochondria play a central role in glucose metabolism and the stimulation of insulin secretion from pancreatic β-cells. In this review, we discuss firstly the regulation and roles of mitochondrial Ca2+ transport in glucose-regulated insulin secretion, and the molecular machinery involved. Next, we discuss the evidence that mitochondrial dysfunction in β-cells is associated with type 2 diabetes, from a genetic, functional and structural point of view, and then the possibility that these changes may in part be mediated by dysregulation of cytosolic Ca2+. Finally, we review the importance of preserved mitochondrial structure and dynamics for mitochondrial gene expression and their possible relevance to the pathogenesis of type 2 diabetes.
Date Issued
2020-11-01
Date Acceptance
2020-08-25
Citation
Cell Calcium, 2020, 91
URI
DOI
ISSN
0143-4160
Publisher
Elsevier
Journal / Book Title
Cell Calcium
Volume
91
Copyright Statement
© 2020 Published by Elsevier Ltd. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
License URL
Sponsor
MRC Programme Grant
Medical Research Council (MRC)
Wellcome Trust
Wellcome Trust
Wellcome Trust
Wellcome Trust
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
INNOVATIVE MEDICINES INITIATIVE
Diabetes UK
Medical Research Council (MRC)
Medical Research Council (MRC)
Diabetes UK
Biotechnology and Biological Sciences Research Council (BBSRC)
Diabetes UK
The Royal Society
Medical Research Council (MRC)
Medical Research Council (MRC)
European Foundation for the Study of Diabetes
European Foundation for the Study of Diabetes
European Foundation for the Study of Diabetes
Diabetes UK
Sun Pharmaceutical Industries Limited
Diabetes UK
Diabetes UK
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32961506
PII: S0143-4160(20)30124-X
Grant Number
MR/R022259/1
MR/R010676/1
212625/Z/18/Z
097816/Z/11/ZR
105603/Z/14/Z
098424/Z/12/ZR
MR/K001981/1
MR/N020472/1
MR/L02036X/1
MR/L02036X/1
115881
15 / 0005275
MR/M012646/1
R26199/CN001
15821
BB/J015873/1
12/0004601
WM100078
MR/K023667/1
16-0323
N/A
n/a
15/0005374
N/A
BDA number 13/0004672
13/0004672
Subjects
Ca(2+)
Insulin secretion
Mitochondria
Type 2 diabetes
β-cells
Publication Status
Published
Coverage Spatial
Netherlands
Article Number
ARTN 102282
Date Publish Online
2020-09-01