Tumour and local lymphoid tissue interaction determines prognosis in high grade serous ovarian cancer
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Tertiary lymphoid structure (TLS) is associated with prognosis in copy number-driven tumours,
including high grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction
with copy-number alterations in HGSOC is not fully understood. In the current study, we confirm
that TLS-high HGSOC patients show significantly better progression free survival. We show that
presence of TLS in HGSOC tumours is associated with B-cell maturation and cytotoxic tumourspecific T-cells activation and proliferation. Additionally, the copy number loss of IL15 and CXCL10
may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed.
Manuscript Click here to view linked References
Lastly, a radiomics-based signature is developed to predict presence of TLS, which independently
predicts PFS in both HGSOC patients and ICI-treated NSCLC patients. Overall, we reveal that TLS
coordinates intratumoural B-cell and T-cell response against HGSOC tumour, while cancer genome
evolves to counteract TLS formation and function.
including high grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction
with copy-number alterations in HGSOC is not fully understood. In the current study, we confirm
that TLS-high HGSOC patients show significantly better progression free survival. We show that
presence of TLS in HGSOC tumours is associated with B-cell maturation and cytotoxic tumourspecific T-cells activation and proliferation. Additionally, the copy number loss of IL15 and CXCL10
may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed.
Manuscript Click here to view linked References
Lastly, a radiomics-based signature is developed to predict presence of TLS, which independently
predicts PFS in both HGSOC patients and ICI-treated NSCLC patients. Overall, we reveal that TLS
coordinates intratumoural B-cell and T-cell response against HGSOC tumour, while cancer genome
evolves to counteract TLS formation and function.
Date Issued
2023-07-18
Date Acceptance
2023-05-30
Citation
Cell Reports Medicine, 2023, 4, pp.1-24
ISSN
2666-3791
Publisher
Elsevier
Start Page
1
End Page
24
Journal / Book Title
Cell Reports Medicine
Volume
4
Copyright Statement
© 2023 The Author(s).
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.sciencedirect.com/science/article/pii/S2666379123002112?via%3Dihub
Publication Status
Published
Date Publish Online
2023-06-21