An innovative route for incorporating pharmaceuticals into biodegradable metal matrices for drug delivery implants
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Metal particles can be welded without significant heating due to severe plastic deformation caused by high pressure torsion. This process has been used to consolidate metallic particles and incorporate ceramic materials into a metallic matrix. The present study demonstrates for the first time that this technique can also be used to incorporate pharmaceuticals into a metallic matrix. In addition, it shows that embedding pharmaceuticals in a biodegradable metal matrix enables the creation of composites with drug delivery capabilities. The results obtained here indicate the successful incorporation of ofloxacin, amphotericin B, and diclofenac sodium into a continuous magnesium matrix. The antifungal and antibacterial activities of the different composites are evaluated along with their drug release kinetics. A new class of biomaterials, biodegradable metals with integrated drug delivery functionality, is introduced in this study.
Date Issued
2025-09-01
Date Acceptance
2025-08-13
Citation
Journal of Materials Research and Technology, 2025, 38, pp.3243-3250
ISSN
2238-7854
Publisher
Elsevier
Start Page
3243
End Page
3250
Journal / Book Title
Journal of Materials Research and Technology
Volume
38
Copyright Statement
© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subjects
ALLOY
Biodegradable metal
COMPOSITE
CONSOLIDATION
Drug delivery
High pressure torsion
HYDROXYAPATITE
Materials Science
Materials Science, Multidisciplinary
Metal matrix composite
Metallurgy & Metallurgical Engineering
Science & Technology
Technology
Publication Status
Published
Date Publish Online
2025-08-13