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  5. Regulation of biomolecular condensates by interfacial protein clusters
 
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Regulation of biomolecular condensates by interfacial protein clusters
File(s)
abg7071_CombinedPDF_v2.pdf (4.82 MB)
Accepted version
Author(s)
Folkmann, Andrew
Putnam, Andrea
Lee, Chiu Fan
Seydoux, Geraldine
Type
Journal Article
Abstract
Pickering emulsions, droplet suspensions stabilized by solid particles, were discovered more than 100 years ago and are well studied in foods, oils, cosmetics, and pharmaceuticals. The particles adsorb to the droplet interface and prevent the emulsion from coarsening. Folkmann et al. report that P granules, biomolecular condensates in Caenorhabditis elegans, are an example of an intracellular Pickering emulsion (see the Perspective by Snead and Gladfelter). Biomolecular condensates are cellular compartments that form without traditional lipid membranes. This work raises the possibility that Pickering agents fulfill the role of membranes in biomolecular condensates. —DJ
Date Issued
2021-09-09
Date Acceptance
2021-06-20
Citation
Science, 2021, 373 (6560), pp.1218-1224
URI
http://hdl.handle.net/10044/1/90700
URL
https://www.science.org/doi/10.1126/science.abg7071
DOI
https://www.dx.doi.org/10.1126/science.abg7071
ISSN
0036-8075
Publisher
AAAS
Start Page
1218
End Page
1224
Journal / Book Title
Science
Volume
373
Issue
6560
Copyright Statement
Copyright reserved
Identifier
https://www.science.org/doi/10.1126/science.abg7071
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PHASE-SEPARATION
P GRANULES
LIQUID DROPLETS
ELEGANS
TRANSITION
EMULSIONS
DYNAMICS
PLATFORM
KINASE
MBK-2
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Intrinsically Disordered Proteins
Oocytes
Protein-Tyrosine Kinases
RNA-Binding Proteins
Zygote
Oocytes
Zygote
Animals
Caenorhabditis elegans
RNA-Binding Proteins
Caenorhabditis elegans Proteins
Protein-Tyrosine Kinases
Intrinsically Disordered Proteins
General Science & Technology
Publication Status
Published
Date Publish Online
2021-09-09
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