Variation of the rates of necrotising enterocolitis in the neonatal networks in England
File(s)NetNec2.pdf (213.59 KB)
Accepted version
Author(s)
Longford, NT
Type
Journal Article
Abstract
Necrotising enterocolitis is an oft-fatal disease of the in
testinal tract in neonates
born prematurely and with low birthweight. We study the vari
ation of its rates
across the neonatal networks (groups of hospital-based neo
natal care units) in
England. We illustrate the problematic nature of hypothesi
s testing for a key
decision which an analysis is meant to inform, and apply an ap
proach based on
decision theory. We emphasise the role of sensitivity analy
sis in dealing with
the ambiguity encountered in the process of eliciting infor
mation about the per-
spective of the client or sponsor for whom the analysis is con
ducted. In the
application based on a fiducial distribution, the likelihoo
d is approximated by a
linearising transformation of the score function.
testinal tract in neonates
born prematurely and with low birthweight. We study the vari
ation of its rates
across the neonatal networks (groups of hospital-based neo
natal care units) in
England. We illustrate the problematic nature of hypothesi
s testing for a key
decision which an analysis is meant to inform, and apply an ap
proach based on
decision theory. We emphasise the role of sensitivity analy
sis in dealing with
the ambiguity encountered in the process of eliciting infor
mation about the per-
spective of the client or sponsor for whom the analysis is con
ducted. In the
application based on a fiducial distribution, the likelihoo
d is approximated by a
linearising transformation of the score function.
Date Issued
2017-05-10
Date Acceptance
2017-01-16
Citation
Statistics in Medicine, 2017, 36 (10), pp.1655-1668
ISSN
1097-0258
Publisher
Wiley
Start Page
1655
End Page
1668
Journal / Book Title
Statistics in Medicine
Volume
36
Issue
10
Copyright Statement
© 2017 John Wiley & Sons, Ltd. This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/sim.7249
Subjects
beta distribution
binary outcomes
decision theory
necrotising enterocolitis
neonatal care
verdict
Algorithms
Analysis of Variance
Biostatistics
Chi-Square Distribution
Decision Theory
England
Enterocolitis, Necrotizing
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Likelihood Functions
Linear Models
Male
Models, Statistical
0104 Statistics
1117 Public Health And Health Services
Statistics & Probability
Publication Status
Published
Date Publish Online
2017-02-17