Variability of neonatal premedication practices for endotracheal intubation and LISA in the UK (NeoPRINT survey)
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Published version
Author(s)
Mimoglu, Ecem
Joyce, Katie
Mohamed, Basma
Sathiyamurthy, Sundar
Banerjee, Jay
Type
Journal Article
Abstract
Objective
The NeoPRINT Survey was designed to assess premedication practices throughout UK NHS Trusts for both neonatal endotracheal intubation and less invasive surfactant administration (LISA).
Design
An online survey consisting of multiple choice and open answer questions covering preferences of premedication for endotracheal intubation and LISA was distributed over a 67-day period. Responses were then analysed using STATA IC 16.0.
Setting
Online survey distributed to all UK Neonatal Units (NNUs).
Participants
The survey evaluated premedication practices for endotracheal intubation and LISA in neonates requiring these procedures.
Main outcome measures
The use of different premedication categories as well as individual medications within each category was analysed to create a picture of typical clinical practice across the UK.
Results
The response rate for the survey was 40.8 % (78/191). Premedication was used in all hospitals for endotracheal intubation but overall, 50 % (39/78) of the units that have responded, use premedications for LISA. Individual clinician preference had an impact on premedication practices within each NNU.
Conclusion
The wide variability on first-line premedication for endotracheal intubation noted in this survey could be overcome using best available evidence through consensus guidance driven by organisations such as British Association of Perinatal |Medicine (BAPM). Secondly, the divisive view around LISA premedication practices noted in this survey requires an answer through a randomised controlled trial.
The NeoPRINT Survey was designed to assess premedication practices throughout UK NHS Trusts for both neonatal endotracheal intubation and less invasive surfactant administration (LISA).
Design
An online survey consisting of multiple choice and open answer questions covering preferences of premedication for endotracheal intubation and LISA was distributed over a 67-day period. Responses were then analysed using STATA IC 16.0.
Setting
Online survey distributed to all UK Neonatal Units (NNUs).
Participants
The survey evaluated premedication practices for endotracheal intubation and LISA in neonates requiring these procedures.
Main outcome measures
The use of different premedication categories as well as individual medications within each category was analysed to create a picture of typical clinical practice across the UK.
Results
The response rate for the survey was 40.8 % (78/191). Premedication was used in all hospitals for endotracheal intubation but overall, 50 % (39/78) of the units that have responded, use premedications for LISA. Individual clinician preference had an impact on premedication practices within each NNU.
Conclusion
The wide variability on first-line premedication for endotracheal intubation noted in this survey could be overcome using best available evidence through consensus guidance driven by organisations such as British Association of Perinatal |Medicine (BAPM). Secondly, the divisive view around LISA premedication practices noted in this survey requires an answer through a randomised controlled trial.
Date Issued
2023-06
Date Acceptance
2023-06-12
Citation
Early Human Development, 2023, 183, pp.1-5
ISSN
0378-3782
Publisher
Elsevier BV
Start Page
1
End Page
5
Journal / Book Title
Early Human Development
Volume
183
Copyright Statement
© 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
http://dx.doi.org/10.1016/j.earlhumdev.2023.105808
Publication Status
Published
Article Number
105808
Date Publish Online
2023-06-15