Endocrine manifestations of malignancy
File(s)
Accepted version
Author(s)
Yousaf, N
Popat, S
Type
Journal Article
Abstract
Endocrine manifestations of cancer are usually paraneoplastic syndromes (i.e. rare systemic manifestations of malignancy caused by non-mass cancer effects). The pathobiology involves the production of hormone and related substances that act in an endocrine or paracrine manner, resulting in systemic manifestations. Two major mechanisms are observed: ectopic hormone production by non-endocrine organs and direct hormone secretion from endocrine malignancies. The most common paraneoplastic syndromes include hypercalcaemia, Cushing's syndrome and syndrome of inappropriate antidiuretic hormone secretion. These may be the presenting feature of an underlying malignancy. Rarer syndromes result from ectopic production of less frequently observed bioactive proteins (e.g. growth hormone-releasing hormone, human chorionic gonadotrophin, insulin-like growth factors, renin, vasoactive intestinal peptide) and iatrogenic causes. Here, we review the spectrum of common and rare endocrine manifestations of malignancy.
Date Issued
2017-08-01
Date Acceptance
2017-08-01
Citation
Medicine (United Kingdom), 2017, 45 (9), pp.547-550
ISSN
1357-3039
Publisher
Elsevier
Start Page
547
End Page
550
Journal / Book Title
Medicine (United Kingdom)
Volume
45
Issue
9
Copyright Statement
© 2017 Published by Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Subjects
1103 Clinical Sciences
Arthritis & Rheumatology
Publication Status
Published