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Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles
File(s)
c6cc04639h.pdf (1.45 MB)
Published version
Author(s)
Davidson, RWM
Fuchter, MJ
Type
Journal Article
Abstract
The N-heterocyclic carbene (NHC)-catalysed redox amidation reaction is poorly developed and usually requires catalytic co-additives for electron-rich amine nucleophiles. We report a masking strategy (using CO2) that couples release of the free amine nucleophile to catalytic turnover, and in doing so, enables direct catalytic redox amidation of electron-rich amines.
Date Issued
2016-07-28
Date Acceptance
2016-07-28
Citation
Chemical Communications, 2016, 52, pp.11638-11641
URI
DOI
ISSN
1364-548X
Publisher
Royal Society of Chemistry
Start Page
11638
End Page
11641
Journal / Book Title
Chemical Communications
Volume
52
Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
License URL
Sponsor
Cancer Research UK
Grant Number
C21484/A6944/A9520/G20971
Subjects
Organic Chemistry
03 Chemical Sciences
Publication Status
Published