Deep venous valve
File(s)
Author(s)
Busuttil, Andrew
Type
Thesis
Abstract
Deep venous reflux is a difficult disorder to treat which result in a significant impact on patients quality of life. Currently, treatment revolves mainly around compression and in extreme cases with deep valve transposition. The aim of this thesis is to develop a material for use as a deep venous valve to implant into patients as a novel treatment modality. This thesis explores characterising and testing a novel polymer designed for this purpose, the design of a testing set up for the prosthetic valve in the lab, prior to large animal testing. A prototype was constructed using electrospinning techniques, in reparation for bench testing of a prototype. The testing strategy for the next phase of testing includes cell culture and small animal protocols for safety and biocompatibility of the material, prior to large animal studies of the prototype prior to applying for MHRA approval.
Version
Open Access
Date Issued
2021-01
Date Awarded
2022-02
Copyright Statement
Creative Commons Attribution NonCommercial NoDerivatives Licence
Advisor
Davies, Alun
Sponsor
The Graham Dixon Charitable Trust
Publisher Department
Department of Surgery & Cancer
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Doctor of Philosophy (PhD)