Non-falciparum malaria infection and IgG seroprevalence among children under 15 years in Nigeria, 2018.
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Published version
Author(s)
Type
Journal Article
Abstract
Plasmodium falciparum (Pf) is the dominant malaria parasite in Nigeria though P. vivax (Pv), P. ovale (Po), and P. malariae (Pm) are also endemic. Blood samples (n = 31,234) were collected from children aged 0-14 years during a 2018 nationwide HIV survey and assayed for Plasmodium antigenemia, Plasmodium DNA, and IgG against Plasmodium MSP1-19 antigens. Of all children, 6.6% were estimated to have Pm infection and 1.4% Po infection with no Pv infections detected. The highest household wealth quintile was strongly protective against infection with Pm (aOR: 0.11, 95% CI: 0.05-0.22) or Po (aOR= 0.01, 0.00-0.10). Overall Pm seroprevalence was 34.2% (95% CI: 33.3-35.2) with lower estimates for Po (12.1%, 11.6-12.5) and Pv (6.3%, 6.0-6.7). Pm seropositivity was detected throughout the country with several local government areas showing >50% seroprevalence. Serological and DNA indicators show widespread exposure of Nigerian children to Pm with lower rates to Po and Pv.
Date Issued
2023-03-13
Date Acceptance
2023-02-27
Citation
Nature Communications, 2023, 14 (1), pp.1-13
ISSN
2041-1723
Publisher
Nature Portfolio
Start Page
1
End Page
13
Journal / Book Title
Nature Communications
Volume
14
Issue
1
Copyright Statement
© 2023 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36914649
PII: 10.1038/s41467-023-37010-0
Subjects
Antigens, Protozoan
Child
Humans
Immunoglobulin G
Malaria
Malaria, Falciparum
Malaria, Vivax
Nigeria
Plasmodium
Plasmodium falciparum
Plasmodium vivax
Seroepidemiologic Studies
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2023-03-13