Recent advancements in the medical treatment of diabetic retinal disease
File(s)
Author(s)
Szymanska, Maja
Mahmood, Daanyaal
Yap, Timothy E
Cordeiro, Maria F
Type
Journal Article
Abstract
Diabetic retinal disease remains one of the most common complications of diabetes mellitus (DM) and a leading cause of preventable blindness. The mainstay of management involves glycemic control, intravitreal, and laser therapy. However, intravitreal therapy commonly requires frequent hospital visits and some patients fail to achieve a significant improvement in vision. Novel and long-acting therapies targeting a range of pathways are warranted, while evidence to support optimal combinations of treatments is currently insufficient. Improved understanding of the molecular pathways involved in pathogenesis is driving the development of therapeutic agents not only targeting visible microvascular disease and metabolic derangements, but also inflammation and accelerated retinal neurodegeneration. This review summarizes the current and emerging treatments of diabetic retinal diseases and provides an insight into the future of managing this important condition.
Date Issued
2021-08-31
Date Acceptance
2021-08-25
Citation
International Journal of Molecular Sciences, 2021, 22 (17), pp.1-25
ISSN
1422-0067
Publisher
MDPI AG
Start Page
1
End Page
25
Journal / Book Title
International Journal of Molecular Sciences
Volume
22
Issue
17
Copyright Statement
© 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000694287400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
diabetic retinopathy
diabetic macular edema
angiogenesis
inflammation
glycemic control
pancreatic transplantation
islet cell transplantation
anti-VEGF
corticosteroids
KALLIKREIN-KININ SYSTEM
FATTY LIVER-DISEASE
DEXAMETHASONE INTRAVITREAL IMPLANT
KIDNEY-PANCREAS TRANSPLANTATION
ENDOTHELIAL PROGENITOR CELLS
ACETONIDE VITREOUS INSERTS
MESENCHYMAL STEM-CELLS
BLOOD-GLUCOSE CONTROL
SINGLE-CHAIN FV
MACULAR EDEMA
Publication Status
Published
Article Number
ARTN 9441
Date Publish Online
2021-08-31