This paper presents for the first time a vision-based tactile sensor (VBTS) enhanced by micro-structured features. Differing from conventional designs where tracking markers are added to unmodified structures, here an interface surface is constructed with micromachined trenches, which allow varying amounts of light to transmit according to the applied force, forming a matrix of bright cross-shaped patterns on the bottom surface. The variation of brightness, wire width, and location of the cross patterns was captured by a camera and used to sense force magnitude and contact location.Compared to previously reported VBTSs, this microstructured sensor increases the sensitivity by magnifying the visual effect of shape distortion. With theoretical and experimental analysis, this sensor achieved a sensitivity of 20 mN. The resolution reached 1 mm for single-point touch. This sensor is entirely soft and compatible with soft robots and wearable electronics. Unlike piezoelectric sensor arrays, it is immune to electrical crosstalk and interference.