Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017
Author(s)
Type
Journal Article
Abstract
We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.
Date Issued
2017-02-23
Date Acceptance
2017-02-23
Citation
Eurosurveillance, 2017, 22 (8), pp.7-12
ISSN
1560-7917
Publisher
European Centre for Disease Prevention and Control
Start Page
7
End Page
12
Journal / Book Title
Eurosurveillance
Volume
22
Issue
8
Copyright Statement
© 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000395815500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
HEMAGGLUTININ
EVOLUTION
SITES
Publication Status
Published
Article Number
30466
Date Publish Online
2017-02-23