Purpose: Despite the surge of melatonin supplement consumption in recent years, data on the prevalence and patterns of melatonin usage in Saudi Arabia is lacking. The aim of this study was to assess the prevalence and pattern of sleep-related melatonin usage among adults in Saudi Arabia.

Methods: This was a cross-sectional, web-based, self-administered survey study conducted across all regions of Saudi Arabia. Participants were recruited from the general population (≥ 18 years). The survey was distributed between February and April 2023. Chi-squared tests and t-tests were performed for comparative bivariate analyses where binary logistic regression was performed to derive the main predictors of melatonin consumption.

Results: Out of 5,606 participants, 536 (10%) were consumers of melatonin. Older age (Adjusted OR = 1.01, 95% CI = 1.01 – 1.02, p=0.002), being a male (Adjusted OR = 1.76, 95% CI = 1.46 – 2.14, p=0.001), individuals with a doctorate degree or an equivalent (adjusted OR 2.37 95% CI = 1.35 – 4.17, p=0.003), perceived poor sleep quality (Adjusted OR = 1.52, 95% CI = 1.10 – 2.11, p=0.01), and being diagnosed with a sleep disorder (Adjusted OR = 2.55, 95% CI = 2.04 – 3.18, p=0.001) were all associated with increased likelihood of sleep-related melatonin usage. 35% of consumers self-reported taking ≥ 1 tablet per day, while 26% of them were uncertain about the dosage they consume.

Conclusion: With a notable prevalence of 10% among the general population in Saudi Arabia, melatonin usage was more common in older adults, males, and those with higher education.