A two-parameter extension of classical nucleation theory.
File(s)1409.5562v1.pdf (3.59 MB)
Accepted version
Author(s)
Lutsko, JF
Durán-Olivencia, MA
Type
Journal Article
Abstract
A two-variable stochastic model for diffusion-limited nucleation is developed using a formalism derived from fluctuating hydrodynamics. The model is a direct generalization of the standard classical nucleation theory (CNT). The nucleation rate and pathway are calculated in the weak-noise approximation and are shown to be in good agreement with direct numerical simulations for the weak-solution/strong-solution transition in globular proteins. We find that CNT underestimates the time needed for the formation of a critical cluster by two orders of magnitude and that this discrepancy is due to the more complex dynamics of the two variable model and not, as often is assumed, a result of errors in the estimation of the free energy barrier.
Date Issued
2015-05-20
Date Acceptance
2015-03-23
Citation
Journal of Physics: Condensed Matter, 2015, 27
ISSN
0953-8984
Publisher
IOP Publishing
Journal / Book Title
Journal of Physics: Condensed Matter
Volume
27
Copyright Statement
© 2015 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Journal of Physics: Condensed Matter. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at http://dx.doi.org/10.1088/0953-8984/27/23/235101
Publication Status
Published
Article Number
235101