Fungal-induced programmed cell death
File(s)
Published version
Author(s)
Williams, Thomas J
Gonzales-Huerta, Luis E
Armstrong-James, Darius
Type
Journal Article
Abstract
Fungal infections are a cause of morbidity in humans, and despite the availability of a range of antifungal treatments, the mortality rate remains unacceptably high. Although our knowledge of the interactions between pathogenic fungi and the host continues to grow, further research is still required to fully understand the mechanism underpinning fungal pathogenicity, which may provide new insights for the treatment of fungal disease. There is great interest regarding how microbes induce programmed cell death and what this means in terms of the immune response and resolution of infection as well as microbe-specific mechanisms that influence cell death pathways to aid in their survival and continued infection. Here, we discuss how programmed cell death is induced by fungi that commonly cause opportunistic infections, including Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, the role of programmed cell death in fungal immunity, and how fungi manipulate these pathways.
Date Issued
2021-03-20
Date Acceptance
2021-03-18
Citation
Journal of Fungi, 2021, 7 (3), pp.1-15
ISSN
2309-608X
Publisher
MDPI
Start Page
1
End Page
15
Journal / Book Title
Journal of Fungi
Volume
7
Issue
3
Copyright Statement
© 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Wellcome Trust
Wellcome Trust
Medical Research Council (MRC)
Cystic Fibrosis Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000633806000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
WTSA MMFI Clinical PhD Fellow
204566/Z/16/Z
MR/R014590/1
SRC 015
Subjects
Science & Technology
Life Sciences & Biomedicine
Microbiology
Mycology
programmed cell death
apoptosis
pyroptosis
necroptosis
extracellular traps
pathogenic fungi
Publication Status
Published
Article Number
ARTN 231
Date Publish Online
2021-03-20