An integrative modelling approach to the mitochondrial cristae
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Mitochondria are implicated in many cellular functions such as energy production and apoptosis but also disease pathogenesis. To effectively perform these roles, the mitochondrial inner membrane has invaginations known as cristae that dramatically increase the surface area. This works to provide more space for membrane proteins that are essential to the roles of mitochondria. While separate components of this have been studied computationally, it remains a challenge to combine elements into an overall model. Here, we present a comprehensive model of a crista junction from a human mitochondrion and the accompanying workflow to construct it. Our coarse-grained representation of a crista shows how various experimentally determined features of organelles can be combined with molecular modelling to give insights into the interactions and dynamics of complicated biological systems. This work is presented as an initial ‘living’ model for this system, intended to be built upon and improved as our understanding, methodology and resources develop.
Date Issued
2025-07-01
Date Acceptance
2025-06-12
Citation
Communications Biology, 2025, 8
ISSN
2399-3642
Publisher
Nature Portfolio
Journal / Book Title
Communications Biology
Volume
8
Copyright Statement
© The Author(s) 2025 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40596661
PII: 10.1038/s42003-025-08381-5
Subjects
ARCHITECTURE
ATP SYNTHASE
BINDS
Biology
CONSTANTS
CONTACT SITE
DYNAMICS
HEALTH
Life Sciences & Biomedicine
Life Sciences & Biomedicine - Other Topics
MICOS
Multidisciplinary Sciences
ORGANIZATION
Science & Technology
Science & Technology - Other Topics
STRUCTURAL BASIS
Publication Status
Published
Coverage Spatial
England
Article Number
972
Date Publish Online
2025-07-01