Mortality attributable to type 2 diabetes mellitus in Latin America and the Caribbean: a comparative risk assessment analysis
File(s)
Accepted version
Author(s)
Carrillo Larco, Rodrigo
Guzman-Vilca, Wilmer Cristobal
Type
Journal Article
Abstract
Introduction: We quantified the proportion and the absolute number of deaths attributable to type 2 diabetes mellitus (T2DM) in Latin America and the Caribbean (LAC) using an estimation approach.
Research design and methods: We combined T2DM prevalence estimates from the NCD Risk Factor Collaboration, relative risks between T2DM and all-cause mortality from a meta-analysis of cohorts in LAC, and death rates from the Global Burden of Disease Study 2019. We estimated population attributable fractions (PAF) and computed the absolute number of attributable deaths in 1990 and 2019 by multiplying the PAFs by the total deaths in each country, year, sex, and five-year age group.
Results: Between 1985 and 2014 in LAC, the proportion of all-cause mortality attributable to T2DM increased from 12.2% to 16.9% in men and from 14.5% to 19.3% in women. In 2019, the absolute number of deaths attributable to T2DM was 349,787 in men and 330,414 in women. The highest death rates (deaths per 100,000 people) in 2019 were in Saint Kitts and Nevis (325 in
men, 229 in women), Guyana (313 in men, 272 in women), and Haiti (269 in men, 265 in women).
Conclusions: A substantial burden of all deaths is attributed to T2DM in LAC. To decrease the mortality attributable to T2DM in LAC, policies are needed to strengthen early diagnosis and management, along with the prevention of complications.
Research design and methods: We combined T2DM prevalence estimates from the NCD Risk Factor Collaboration, relative risks between T2DM and all-cause mortality from a meta-analysis of cohorts in LAC, and death rates from the Global Burden of Disease Study 2019. We estimated population attributable fractions (PAF) and computed the absolute number of attributable deaths in 1990 and 2019 by multiplying the PAFs by the total deaths in each country, year, sex, and five-year age group.
Results: Between 1985 and 2014 in LAC, the proportion of all-cause mortality attributable to T2DM increased from 12.2% to 16.9% in men and from 14.5% to 19.3% in women. In 2019, the absolute number of deaths attributable to T2DM was 349,787 in men and 330,414 in women. The highest death rates (deaths per 100,000 people) in 2019 were in Saint Kitts and Nevis (325 in
men, 229 in women), Guyana (313 in men, 272 in women), and Haiti (269 in men, 265 in women).
Conclusions: A substantial burden of all deaths is attributed to T2DM in LAC. To decrease the mortality attributable to T2DM in LAC, policies are needed to strengthen early diagnosis and management, along with the prevention of complications.
Date Acceptance
2022-01-18
Citation
BMJ Open Diabetes Research and Care, 10
ISSN
2052-4897
Publisher
BMJ Publishing Group
Journal / Book Title
BMJ Open Diabetes Research and Care
Volume
10
Copyright Statement
© Author(s) (or their
employer(s)) 2022. Re-use
permitted under CC BY.
Published by BMJ
employer(s)) 2022. Re-use
permitted under CC BY.
Published by BMJ
License URL
Sponsor
Wellcome Trust
Identifier
https://drc.bmj.com/content/bmjdrc/10/1/e002673.full.pdf
Grant Number
214185/Z/18/Z
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
population health
risk assessment
TRENDS
population health
risk assessment
1103 Clinical Sciences
Publication Status
Published