Methodological challenges of measuring brain volumes and cortical thickness in idiopathic Normal Pressure Hydrocephalus with a surface-based approach
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Identifying disease-specific imaging features of idiopathic Normal Pressure Hydrocephalus (iNPH) is crucial to develop accurate diagnoses, although the abnormal brain anatomy of patients with iNPH creates challenges in neuroimaging analysis. We quantified cortical thickness and volume using FreeSurfer 7.3.2 in 19 patients with iNPH, 28 patients with Alzheimer's disease (AD), and 30 healthy controls (HC). We noted the frequent need for manual correction of the automated segmentation in iNPH and examined the effect of correction on the results. We identified statistically significant higher proportion of volume changes associated with manual edits in individuals with iNPH compared to both HC and patients with AD. Changes in cortical thickness and volume related to manual correction were also partly correlated with the severity of radiological features of iNPH. We highlight the challenges posed by the abnormal anatomy in iNPH when conducting neuroimaging analysis and emphasise the importance of quality checking and correction in this clinical population.
Date Issued
2024-07-19
Date Acceptance
2024-06-28
Citation
Frontiers in Neuroscience, 2024, 18
ISSN
1662-453X
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Neuroscience
Volume
18
Copyright Statement
Copyright © 2024 Del Giovane, David, Kolanko, Gontsarova, Parker, Hampshire, Sharp, Malhotra and Carswell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1366029/abstract
Publication Status
Published
Article Number
1366029
Date Publish Online
2024-07-19