We specify the semiclassical no-boundary wave function of the Universe without relying on a functional integral of any kind. The wave function is given as a sum of specific saddle points of the dynamical theory that satisfy conditions of regularity on the geometry and field and that together yield a time-neutral state that is normalizable in an appropriate inner product. This specifies a predictive framework of semiclassical quantum cosmology that is adequate to make probabilistic predictions, which are in agreement with observations in simple models. The use of holography to go beyond the semiclassical approximation is briefly discussed.