The interplay of leukemia cells and the bone marrow microenvironment
File(s)
Accepted version
Author(s)
Duarte, Delfim
Hawkins, Edwin D
Lo Celso, Cristina
Type
Journal Article
Abstract
The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic cells are poorly understood. Recent development of novel imaging technology and preclinical disease models have advanced our comprehension of leukemia-microenvironment crosstalk and have potential implications for development of novel treatment options.
Date Issued
2018-04-05
Date Acceptance
2018-02-09
Citation
Blood, 2018, 131 (14), pp.1507-1511
ISSN
1528-0020
Publisher
American Society of Hematology
Start Page
1507
End Page
1511
Journal / Book Title
Blood
Volume
131
Issue
14
Copyright Statement
© 2018 American Society of Hematology
Sponsor
Kay Kendall Leukemia Fund
Human Frontier Science Program
Bloodwise
Commission of the European Communities
European Hematology Association
Biotechnology and Biological Sciences Research Council (BBSRC)
Bloodwise
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29487069
PII: blood-2017-12-784132
Grant Number
KKL460
rgp0051/2011
12033
337066
n/a
BB/L023776/1
15040
Subjects
1102 Cardiovascular Medicine And Haematology
1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
Immunology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2018-02-27