Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function
File(s)Salmonella-SPI-2-type-III-secretion.pdf (558.18 KB)
Published version
Author(s)
Cerny, Ondrej
Holden, David
Type
Journal Article
Abstract
Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. In this review, we discuss processes that are hijacked by SPI-2 T3SS effectors and how this affects DC biology and the activation of T cell responses.
Date Issued
2019-11-01
Date Acceptance
2019-01-10
Citation
Immunology Letters, 2019, 215, pp.35-39
ISSN
0165-2478
Publisher
Elsevier
Start Page
35
End Page
39
Journal / Book Title
Immunology Letters
Volume
215
Copyright Statement
© 2019 The Authors. Published by Elsevier B.V. on behalf of European Federation of Immunological Societies. This is an open access article under
the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
Sponsor
Medical Research Council (MRC)
Grant Number
MR/P028225/1
Subjects
Antigen presentation
Dendritic cells
Migration
Salmonella
T cell culling
T cells
Immunology
1107 Immunology
Publication Status
Published
Date Publish Online
2019-02-13