Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
File(s)
Author(s)
TA, Kulendran M Stebbing JF Marks CM Rockall
Type
Journal Article
Abstract
It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.
Date Issued
2011-03-29
Citation
Cancers, 2011, 3, pp.1622-1638
URI
DOI
ISSN
2072-6694
Start Page
1622
End Page
1638
Journal / Book Title
Cancers
Volume
3
Issue
2
Copyright Statement
© by the authors; licensee MDPI , Basel, S
witzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
License URL
Description
OA paer, OK TO ADD.
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/24212777
cancers3021622
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
2