A lipophilic copper(II) complex as an optical probe for intracellular detection of NO
File(s)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
A new chemical sensor for cellular imaging of NO is presented. This cell
-
permeable probe is
ba
sed on a complex where copper(II) is coordinated to a tridentate ligand substituted with a
fluorophore (NBD) and an octyl group
.
The fluorescent response of this complex towards a
range of reactive species
(namely NO, NO
2
-
, NO
3
-
, H
2
O
2
, ClO
-
, O
2
-
and ONOO
-
)
has been
studied
in vitro
showing that the probe is hig
h
ly selective for NO.
The probe is readily taken
up by cells and is able to image the cellular concentrations of NO
-
permeable probe is
ba
sed on a complex where copper(II) is coordinated to a tridentate ligand substituted with a
fluorophore (NBD) and an octyl group
.
The fluorescent response of this complex towards a
range of reactive species
(namely NO, NO
2
-
, NO
3
-
, H
2
O
2
, ClO
-
, O
2
-
and ONOO
-
)
has been
studied
in vitro
showing that the probe is hig
h
ly selective for NO.
The probe is readily taken
up by cells and is able to image the cellular concentrations of NO
Date Issued
2016-12-07
Date Acceptance
2016-10-12
Citation
Dalton Transactions, 2016, 45, pp.18177-18182
ISSN
1477-9226
Publisher
Royal Society of Chemistry
Start Page
18177
End Page
18182
Journal / Book Title
Dalton Transactions
Volume
45
Copyright Statement
© The Royal Society of Chemistry 2016
Subjects
Science & Technology
Physical Sciences
Chemistry, Inorganic & Nuclear
Chemistry
NITRIC-OXIDE SYNTHASE
LIVING CELLS
FLUORESCENT-PROBES
AQUEOUS-SOLUTION
VISUALIZATION
DISEASE
COBALT
Inorganic & Nuclear Chemistry
0302 Inorganic Chemistry
0399 Other Chemical Sciences
Publication Status
Published
Date Publish Online
2016-10-18