Sensory adaptation in naive peripheral CD4 T cells
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Published version
Author(s)
Type
Journal Article
Abstract
T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands
control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid
organs. Here we show that pMHC contact modulates the expression of CD5 by naive
CD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levels
in T cells deprived of pMHC contact are predictive of elevated Ca2 responses to subsequent
TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact
may be important for regulating naive CD4 T cell responsiveness.
control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid
organs. Here we show that pMHC contact modulates the expression of CD5 by naive
CD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levels
in T cells deprived of pMHC contact are predictive of elevated Ca2 responses to subsequent
TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact
may be important for regulating naive CD4 T cell responsiveness.
Date Issued
2001-11-05
Date Acceptance
2001-10-01
Citation
Journal of Experimental Medicine, 2001, 194 (9), pp.1253-1261
ISSN
1540-9538
Publisher
Rockefeller University Press
Start Page
1253
End Page
1261
Journal / Book Title
Journal of Experimental Medicine
Volume
194
Issue
9
Copyright Statement
© 2001 Rockefeller University Press
Identifier
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Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
IMMUNOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
T cell receptor repertoire
T cell responsiveness
CD5
MHC contact
p56(lck)
CLASS-II MOLECULES
ANTIGEN RECEPTOR
POSITIVE SELECTION
NEGATIVE REGULATION
IN-VIVO
HOMEOSTATIC PROLIFERATION
SIGNAL-TRANSDUCTION
THYMIC SELECTION
TCR SIGNALS
B-CELLS
Adaptation, Physiological
Animals
Antigens, CD5
CD4-Positive T-Lymphocytes
H-2 Antigens
Haplotypes
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Major Histocompatibility Complex
Mice
Medical And Health Sciences
Publication Status
Published