A systematic review and meta-analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer
Author(s)
Type
Journal Article
Abstract
Background: Screening programmes exist in many countries for colorectal cancer. In recent years, there has been a
drive for a non-invasive screening marker of higher sensitivity and specificity. Stool-based pyruvate kinase isoenzyme
M2 (M2-PK) is one such biomarker under investigation. The aim of this systematic review and meta-analysis is to
determine the diagnostic accuracy, sensitivity and specificity of M2-PK as a screening tool in colorectal cancer.
Methods: A literature search of Ovid Medline, EMBASE and Google Scholar was carried out. The search strategy was
restricted to human subjects and studies published in English. Data on sensitivity and specificity were extracted and
pooled. Statistical analysis was conducted using summary receiver operating characteristic (SROC) curve methodology.
Results: A total of eight studies were suitable for data synthesis and analysis. Our analysis showed a pooled sensitivity
and specificity for M2-PK to be 79% (CI 73%–83%) and 80% (CI 73%–86%), respectively. The accuracy of M2-PK was 0.85
(0.82–0.88).
Conclusion: Faecal M2-PK assay has a relatively good sensitivity and specificity and high accuracy for screening
colorectal cancer.
drive for a non-invasive screening marker of higher sensitivity and specificity. Stool-based pyruvate kinase isoenzyme
M2 (M2-PK) is one such biomarker under investigation. The aim of this systematic review and meta-analysis is to
determine the diagnostic accuracy, sensitivity and specificity of M2-PK as a screening tool in colorectal cancer.
Methods: A literature search of Ovid Medline, EMBASE and Google Scholar was carried out. The search strategy was
restricted to human subjects and studies published in English. Data on sensitivity and specificity were extracted and
pooled. Statistical analysis was conducted using summary receiver operating characteristic (SROC) curve methodology.
Results: A total of eight studies were suitable for data synthesis and analysis. Our analysis showed a pooled sensitivity
and specificity for M2-PK to be 79% (CI 73%–83%) and 80% (CI 73%–86%), respectively. The accuracy of M2-PK was 0.85
(0.82–0.88).
Conclusion: Faecal M2-PK assay has a relatively good sensitivity and specificity and high accuracy for screening
colorectal cancer.
Date Issued
2015-02-13
Date Acceptance
2015-01-08
Citation
World Journal of Surgical Oncology, 2015, 13
ISSN
1477-7819
Publisher
BioMed Central
Journal / Book Title
World Journal of Surgical Oncology
Volume
13
Copyright Statement
© 2015 Uppara et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain
Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,
unless otherwise stated.
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain
Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,
unless otherwise stated.
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
Surgery
Colorectal cancer
Faecal test
Pyruvate kinase isoenzymatic assay
OCCULT BLOOD-TEST
PROSPECTIVE MULTICENTER
TUMOR M2-PK
SPECIFICITY
SENSITIVITY
COLONOSCOPY
BIOMARKER
NEOPLASIA
TESTS
Publication Status
Published
Article Number
48