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  5. Patient-specific virtual stent-graft deployment for Type B aortic dissection: a pilot study of the impact of stent-graft length
 
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Patient-specific virtual stent-graft deployment for Type B aortic dissection: a pilot study of the impact of stent-graft length
File(s)
fphys-12-718140.pdf (3.5 MB)
Published version
Author(s)
Kan, Xiaoxin
Ma, Tao
Dong, Zhihui
Xu, Xiao
Type
Journal Article
Abstract
Thoracic endovascular aortic repair (TEVAR) has been accepted as a standard treatment option for complicated type B aortic dissection. Distal stent-graft induced new entry (SINE) is recognized as one of the main post-TEVAR complications, which can lead to fatal prognosis. Previous retrospective cohort studies suggested that short stent-graft (SG) length (<165 mm) might correlate with increased risk of distal SINE. However, the influence of SG length on changes in local biomechanical conditions before and after TEVAR is unknown. In this paper, we aim to address this issue using a virtual SG deployment simulation model developed for application in type B aortic dissection. Our model incorporates detailed SG design and hyperelastic behaviour of the aortic wall. By making use of patient-specific geometry reconstructed from pre-TEVAR computed tomography angiography (CTA) scan, our model can predict post-TEVAR SG configuration and wall stress. Virtual SG deployment simulations were performed on a patient who underwent TEVAR with a short SG (158 mm in length), mimicking the actual clinical procedure. Further simulations were carried out on the same patient geometry but with different SG lengths (183 mm and 208 mm) in order to evaluate the effect of SG length on changes in local stress in the treated aorta.
Date Issued
2021-07-26
Date Acceptance
2021-07-05
Citation
Frontiers in Physiology, 2021, 12
URI
http://hdl.handle.net/10044/1/90784
DOI
https://www.dx.doi.org/10.3389/fphys.2021.718140
ISSN
1664-042X
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Physiology
Volume
12
Copyright Statement
© 2021 Kan, Ma, Dong and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
https://creativecommons.org/licenses/by/4.0/
Sponsor
The Royal Society
Grant Number
IE161052
Subjects
Science & Technology
Life Sciences & Biomedicine
Physiology
type B aortic dissection
virtual stent-graft deployment
finite element analysis
stent-induced new entry
wall stress
ENDOVASCULAR REPAIR
RISK-FACTORS
SIMULATION
ENTRY
finite element analysis
stent-induced new entry
type B aortic dissection
virtual stent-graft deployment
wall stress
0606 Physiology
1116 Medical Physiology
1701 Psychology
Publication Status
Published
Article Number
ARTN 718140
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