Use of kisspeptin to trigger oocyte maturation during in vitro fertilisation (IVF) treatment
File(s)
Published version
Author(s)
Sharma, Bhavna
Koysombat, Kanyada
Dhillo, Waljit
Abbara, Ali
Type
Journal Article
Abstract
Infertility is a major global health issue and is associated with significant psychological distress for afflicted couples. In vitro
fertilisation (IVF) utilises supra-physiological doses of stimulatory hormones to induce the growth of multiple ovarian follicles to
enable surgical retrieval of several oocytes for subsequent fertilisation and implantation into the maternal endometrium. The
supra-physiological degree of ovarian stimulation can lead to potential risks during IVF treatment, including ovarian
hyperstimulation syndrome (OHSS) and multiple pregnancy.
The choice of oocyte maturation trigger, such as human chorionic gonadotrophin (hCG) or gonadotrophin releasing hormone
agonist (GnRHa), can impact both the efficacy of IVF treatment with a bearing on luteal phase hormonal dynamics and thus the
degree of luteal phase support required to maintain optimal pregnancy rates, as well as on safety of treatment with particular
respect to the risk of OHSS. Kisspeptin regulates gonadotrophin releasing hormone (GnRH) release and is therefore a key regulator
of the hypothalamo-pituitary-gonadal (HPG) axis. Kisspeptin has been shown to be requisite for the occurrence of the physiological
ovulatory luteinising hormone (LH) surge. In this review, we discuss the potential use of kisspeptin as a novel trigger of oocyte
maturation.
fertilisation (IVF) utilises supra-physiological doses of stimulatory hormones to induce the growth of multiple ovarian follicles to
enable surgical retrieval of several oocytes for subsequent fertilisation and implantation into the maternal endometrium. The
supra-physiological degree of ovarian stimulation can lead to potential risks during IVF treatment, including ovarian
hyperstimulation syndrome (OHSS) and multiple pregnancy.
The choice of oocyte maturation trigger, such as human chorionic gonadotrophin (hCG) or gonadotrophin releasing hormone
agonist (GnRHa), can impact both the efficacy of IVF treatment with a bearing on luteal phase hormonal dynamics and thus the
degree of luteal phase support required to maintain optimal pregnancy rates, as well as on safety of treatment with particular
respect to the risk of OHSS. Kisspeptin regulates gonadotrophin releasing hormone (GnRH) release and is therefore a key regulator
of the hypothalamo-pituitary-gonadal (HPG) axis. Kisspeptin has been shown to be requisite for the occurrence of the physiological
ovulatory luteinising hormone (LH) surge. In this review, we discuss the potential use of kisspeptin as a novel trigger of oocyte
maturation.
Date Issued
2022-09-06
Date Acceptance
2022-08-15
Citation
Frontiers in Endocrinology, 2022, 13, pp.1-9
ISSN
1664-2392
Publisher
Frontiers Media
Start Page
1
End Page
9
Journal / Book Title
Frontiers in Endocrinology
Volume
13
Copyright Statement
© 2022 Sharma, Koysombat, Comninos, Dhillo and Abbara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Sponsor
National Institute for Health Research
Identifier
https://www.frontiersin.org/articles/10.3389/fendo.2022.972137/full
Grant Number
CS-2018-18-ST2-002
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
IVF
kisspeptin
in vitro fertilisation
oocyte
fertility
ovarian hyperstimulation syndrome
OHSS
OVARIAN HYPERSTIMULATION SYNDROME
EMBRYO-TRANSFER
SYNDROME OHSS
HIGH-RISK
WOMEN
ANTAGONIST
RECEPTORS
CYCLES
AXIS
IVF
OHSS
fertility
in vitro fertilisation
kisspeptin
oocyte
ovarian hyperstimulation syndrome
Chorionic Gonadotropin
Female
Fertilization in Vitro
Gonadotropin-Releasing Hormone
Humans
Kisspeptins
Luteinizing Hormone
Oocytes
Ovarian Hyperstimulation Syndrome
Pregnancy
Oocytes
Humans
Ovarian Hyperstimulation Syndrome
Chorionic Gonadotropin
Luteinizing Hormone
Fertilization in Vitro
Pregnancy
Female
Gonadotropin-Releasing Hormone
Kisspeptins
1103 Clinical Sciences
1111 Nutrition and Dietetics
Publication Status
Published
Article Number
972137
Date Publish Online
2022-09-06