Measurement of electrophysiological signals in vitro using high-performance organic electrochemical transistors
File(s)
Published version
Author(s)
Tyrrell, James
Boutelle, Martyn
Campbell, Alasdair
Type
Journal Article
Abstract
Biological environments use ions in charge transport for information transmission. The properties of mixed electronic and ionic conductivity in organic materials make them ideal candidates to transduce physiological information into electronically processable signals. A device proven to be highly successful in measuring such information is the organic electrochemical transistor (OECT). Previous electrophysiological measurements performed using OECTs show superior signal‐to‐noise ratios than electrodes at low frequencies. Subsequent development has significantly improved critical performance parameters such as transconductance and response time. Here, interdigitated‐electrode OECTs are fabricated on flexible substrates, with one such state‐of‐the‐art device achieving a peak transconductance of 139 mS with a 138 µs response time. The devices are implemented into an array with interconnects suitable for micro‐electrocorticographic application and eight architecture variations are compared. The two best‐performing arrays are subject to the full electrophysiological spectrum using prerecorded signals. With frequency filtering, kHz‐scale frequencies with 10 µV‐scale voltages are resolved. This is supported by a novel quantification of the noise, which compares the gate voltage input and drain current output. These results demonstrate that high‐performance OECTs can resolve the full electrophysiological spectrum and suggest that superior signal‐to‐noise ratios could be achieved in high frequency measurements of multiunit activity.
Date Issued
2021-01-04
Date Acceptance
2020-09-08
Citation
Advanced Functional Materials, 2021, 31 (1), pp.1-12
ISSN
1616-301X
Publisher
Wiley
Start Page
1
End Page
12
Journal / Book Title
Advanced Functional Materials
Volume
31
Issue
1
Copyright Statement
© 2020 The Authors. Published by Wiley‐VCH GmbH
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://onlinelibrary.wiley.com/doi/10.1002/adfm.202007086
Grant Number
EP/K503381/1
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
bioelectronics
electrophysiology
interdigitated electrode arrays
organic electrochemical transistors
plastic electronics
BRAIN
STATE
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Materials
Publication Status
Published
Date Publish Online
2020-09-24