Novel positron emission tomography tracers for imaging vascular inflammation
File(s)
Author(s)
Corovic, Andrej
Wall, Christopher
Mason, Justin C
Rudd, James HF
Tarkin, Jason M
Type
Journal Article
Abstract
Purpose of Review
To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field.
Recent Findings
While PET imaging with 18F-fluorodeoxyglucose (FDG) can provide a useful marker of disease activity in several vascular inflammatory diseases, including atherosclerosis and large-vessel vasculitis, this tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal. To overcome these limitations, research is ongoing to identify novel PET tracers that can more accurately track individual components of vascular immune responses. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies.
Summary
Future research is needed to realise the true clinical translational value of PET imaging in vascular inflammatory diseases.
To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field.
Recent Findings
While PET imaging with 18F-fluorodeoxyglucose (FDG) can provide a useful marker of disease activity in several vascular inflammatory diseases, including atherosclerosis and large-vessel vasculitis, this tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal. To overcome these limitations, research is ongoing to identify novel PET tracers that can more accurately track individual components of vascular immune responses. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies.
Summary
Future research is needed to realise the true clinical translational value of PET imaging in vascular inflammatory diseases.
Date Issued
2020-08-09
Date Acceptance
2020-08-01
Citation
Current Cardiology Reports, 2020, 22 (10), pp.1-11
ISSN
1523-3782
Publisher
Springer
Start Page
1
End Page
11
Journal / Book Title
Current Cardiology Reports
Volume
22
Issue
10
Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000561802500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
PET
Inflammation
Atherosclerosis
Large-vessel vasculitis
Molecular imaging
Non-invasive imaging
ATHEROSCLEROTIC PLAQUE INFLAMMATION
LARGE VESSEL VASCULITIS
RECEPTOR 4 EXPRESSION
TARGETING P-SELECTIN
RISK-FACTORS
NONINVASIVE ASSESSMENT
IMPROVES PREDICTION
FDG UPTAKE
MACROPHAGE
Publication Status
Published
Article Number
ARTN 119
Date Publish Online
2020-08-09