Advancing clinical trial design in pulmonary hypertension
File(s)
Author(s)
Type
Journal Article
Abstract
In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clinical trial designs in pulmonary hypertension and here discusses their merits, limitations and challenges to implementation of novel approaches.
Date Issued
2013-01-01
Date Acceptance
2013-01-01
Citation
Pulmonary Circulation, 2013, 3 (1), pp.217-225
ISSN
2045-8940
Publisher
SAGE Publications
Start Page
217
End Page
225
Journal / Book Title
Pulmonary Circulation
Volume
3
Issue
1
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209981400032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Respiratory System
Cardiovascular System & Cardiology
pulmonary arterial hypertension
clinical trial design
adaptive designs
modeling and simulation
Bayesian modeling
group sequential designs
population enrichment
ARTERIAL-HYPERTENSION
END-POINTS
ENRICHMENT DESIGNS
ADAPTIVE DESIGNS
Publication Status
Published
Date Publish Online
2013-01-01