SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’
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Published version
Author(s)
Type
Journal Article
Abstract
In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8%-4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7%-100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95%CI:11.0%-28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95%CrI:17.2%-36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.
Date Issued
2021-07-19
Date Acceptance
2021-06-21
Citation
Nature Communications, 2021, 12 (4383), pp.1-11
ISSN
2041-1723
Publisher
Nature Research
Start Page
1
End Page
11
Journal / Book Title
Nature Communications
Volume
12
Issue
4383
Copyright Statement
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
Medical Research Council (MRC)
Wellcome Trust
Identifier
https://www.nature.com/articles/s41467-021-24622-7
Grant Number
MR/R015600/1
213494/Z/18/Z
Publication Status
Published
Date Publish Online
2021-07-19