Speaking the host language: how Salmonella effector proteins manipulate the host
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Published version
Author(s)
Type
Journal Article
Abstract
Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been described as mediating eukaryotic-like, biochemical post-translational modifications (PTMs) of host proteins, altering the outcome of infection. The downstream changes mediated by an effector's enzymatic activity range from highly specific to multifunctional, and altogether their combined action impacts the function of an impressive array of host cellular processes, including signal transduction, membrane trafficking, and both innate and adaptive immune responses. Salmonella and related Gram-negative pathogens have been a rich resource for the discovery of unique enzymatic activities, expanding our understanding of host signalling networks, bacterial pathogenesis as well as basic biochemistry. In this review, we provide an up-to-date assessment of host manipulation mediated by the Salmonella type III secretion system injectosome, exploring the cellular effects of diverse effector activities with a particular focus on PTMs and the implications for infection outcomes. We also highlight activities and functions of numerous effectors that remain poorly characterized.
Date Issued
2023-06
Date Acceptance
2023-05-10
Citation
Microbiology, 2023, 169 (6), pp.1-30
ISSN
1350-0872
Publisher
Microbiology Society
Start Page
1
End Page
30
Journal / Book Title
Microbiology
Volume
169
Issue
6
Copyright Statement
© 2023 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between
the Microbiology Society and the corresponding author’s institution.
the Microbiology Society and the corresponding author’s institution.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37279149
Subjects
Bacteria
Bacterial Proteins
Host-Pathogen Interactions
Salmonella
Type III Secretion Systems
Virulence Factors
biochemical mechanism
intracellular pathogen
post-translational modification
Salmonella pathogenesis
type III effector protein
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2023-06-06