Follicular regulatory T cells can access the germinal center independently of CXCR5
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3+ regulatory T cells located within GCs. Relatively little is known about the exact role of Tfr cells within the GC and how they exert their suppressive function. A unique feature of Tfr cells is their reported CXCR5-dependent localization to the GC. Here, we show that the lack of CXCR5 on Foxp3+ regulatory T cells results in a reduced frequency, but not an absence, of GC-localized Tfr cells. This reduction in Tfr cells is not sufficient to alter the magnitude or output of the GC response. This demonstrates that additional, CXCR5-independent mechanisms facilitate Treg cell homing to the GC.
Date Issued
2020-01-21
Date Acceptance
2019-12-19
Citation
Cell Reports, 2020, 30 (3), pp.611-619.e4
ISSN
2211-1247
Publisher
Elsevier
Start Page
611
End Page
619.e4
Journal / Book Title
Cell Reports
Volume
30
Issue
3
Copyright Statement
© 2019 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508359200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
RESPONSES
HELPER
INTERLEUKIN-2
Publication Status
Published
Date Publish Online
2020-01-21