PP2A phosphatase as an emerging viral host factor
File(s)
Published version
Author(s)
Barski, Michal
Minnell, Jordan
Maertens, Goedele
Type
Journal Article
Abstract
Protein phosphatase 2A (PP2A) is one of the most ubiquitous cellular proteins and is responsible for the vast majority of Ser/Thr phosphatase activity in eukaryotes. PP2A is a heterotrimer, and its assembly, intracellular localization, enzymatic activity, and substrate specificity are subject to dynamic regulation. Each of its subunits can be targeted by viral proteins to hijack and modulate its activity and downstream signaling to the advantage of the virus. Binding to PP2A is known to be essential to the life cycle of many viruses and seems to play a particularly crucial role for oncogenic viruses, which utilize PP2A to transform infected cells through controlling the cell cycle and apoptosis. Here we summarise the latest developments in the field of PP2A viral targeting; in particular recent discoveries of PP2A hijacking through molecular mimicry of a B56-specific motif by several different viruses. We also discuss the potential as well as shortcomings for therapeutic intervention in the face of our current understanding of viral PP2A targeting.
Date Issued
2021-08-04
Date Acceptance
2021-07-20
Citation
Frontiers in Cellular and Infection Microbiology, 2021, 11
ISSN
2235-2988
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Cellular and Infection Microbiology
Volume
11
Copyright Statement
© 2021 Barski, Minnell and Maertens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Sponsor
Wellcome Trust
Grant Number
107005/Z/15/Z
Subjects
0601 Biochemistry and Cell Biology
0605 Microbiology
Publication Status
Published
Article Number
ARTN 725615