Metabolomics - the stethoscope for the 21st century
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Metabolomics offers systematic identification and quantification of all metabolic products from the human body. This field could provide clinicians with new sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualised level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential applications of metabolomics in clinical practice and discuss the translational challenges that the field faces. We searched PubMed, Medline and Embase for primary and secondary research articles regarding clinical applications of metabolomics. Metabolic profiling can be performed using mass spectrometry and NMR based techniques using a variety of biological samples. This is carried out in vivo or in vitro following careful sample collection, preparation and analysis. The potential clinical applications constitute disruptive innovations in their respective specialities, particularly oncology and metabolic medicine. Outstanding issues currently preventing widespread clinical use centre around scalability of data interpretation, standardisation of sample handling practice and e-infrastructure. Routine utilisation of metabolomics at a patient and population level will constitute an integral part of future healthcare provision.
Date Issued
2020-12-03
Date Acceptance
2020-11-29
Citation
Medical Principles and Practice, 2020, 30 (4), pp.301-310
ISSN
1011-7571
Publisher
Karger
Start Page
301
End Page
310
Journal / Book Title
Medical Principles and Practice
Volume
30
Issue
4
Copyright Statement
© 2020 The Author(s)
Published by S. Karger AG, Basel
karger@karger.com
www.karger.com/mpp
Significance of the Study
• Metabolomics encompasses the systematic identification and quantification of all metabolic products
from the human body.
• This field could provide clinicians with novel sets of diagnostic biomarkers for disease states, in addition to quantifying treatment response to medications at an individualized level.
• Outstanding issues preventing widespread clinical use are scalability of data interpretation, standardization of sample handling practice, and e-infrastructure.
DOI: 10.1159/000513545
Keywords
Metabolomics · Personalised medicine · Precision medicine
Abstract
Metabolomics encompasses the systematic identification
and quantification of all metabolic products in the human
body. This field could provide clinicians with novel sets of
diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualized level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential
applications of metabolomics in clinical practice, and discuss
the translational challenges that the field faces. We searched
PubMed, MEDLINE, and EMBASE for primary and secondary
research articles regarding clinical applications of metaboloThis is an Open Access article licensed under the Creative Commons
Attribution-NonCommercial-4.0 International License (CC BY-NC)
(http://www.karger.com/Services/OpenAccessLicense), applicable to
the online version of the article only. Usage and distribution for commercial purposes requires written permission.
Published by S. Karger AG, Basel
karger@karger.com
www.karger.com/mpp
Significance of the Study
• Metabolomics encompasses the systematic identification and quantification of all metabolic products
from the human body.
• This field could provide clinicians with novel sets of diagnostic biomarkers for disease states, in addition to quantifying treatment response to medications at an individualized level.
• Outstanding issues preventing widespread clinical use are scalability of data interpretation, standardization of sample handling practice, and e-infrastructure.
DOI: 10.1159/000513545
Keywords
Metabolomics · Personalised medicine · Precision medicine
Abstract
Metabolomics encompasses the systematic identification
and quantification of all metabolic products in the human
body. This field could provide clinicians with novel sets of
diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualized level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential
applications of metabolomics in clinical practice, and discuss
the translational challenges that the field faces. We searched
PubMed, MEDLINE, and EMBASE for primary and secondary
research articles regarding clinical applications of metaboloThis is an Open Access article licensed under the Creative Commons
Attribution-NonCommercial-4.0 International License (CC BY-NC)
(http://www.karger.com/Services/OpenAccessLicense), applicable to
the online version of the article only. Usage and distribution for commercial purposes requires written permission.
License URL
Sponsor
National Institute of Health Research
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33271569
PII: 000513545
Subjects
Metabolomics
Personalised medicine
Precision medicine
Microbiology
1117 Public Health and Health Services
Publication Status
Published
Coverage Spatial
Switzerland
Date Publish Online
2020-12-03