TAM receptors in the pathophysiology of liver disease
File(s)
Author(s)
Flint, Emilio
Triantafyllou, Evangelos
Bernsmeier, Christine
Type
Journal Article
Abstract
TAM receptors (Tyro3, Axl and MerTK) are a family of tyrosine kinase receptors that are expressed in a variety of cell populations, including liver parenchymal and non-parenchymal cells. These receptors are vital for immune homeostasis, as they regulate the innate immune response by suppressing inflammation via toll-like receptor inhibition and by promoting tissue resolution through efferocytosis. However, there is increasing evidence indicating that aberrant TAM receptor signaling may play a role in pathophysiological processes in the context of liver disease. This review will explore the roles of TAM receptors and their ligands in liver homeostasis as well as a variety of disease settings, including acute liver injury, steatosis, fibrosis, cirrhosis-associated immune dysfunction and hepatocellular carcinoma. A better understanding of our current knowledge of TAM receptors in liver disease may identify new opportunities for disease monitoring as well as novel therapeutic targets. Nonetheless, this review also aims to highlight areas where further research on TAM receptor biology in liver disease is required.
Date Issued
2022-01-15
Date Acceptance
2021-12-27
Citation
Livers, 2022, 2 (1), pp.15-29
ISSN
2673-4389
Publisher
MDPI
Start Page
15
End Page
29
Journal / Book Title
Livers
Volume
2
Issue
1
Copyright Statement
© 2022 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
License URL
Sponsor
Rosetrees Trust
Rosetrees Trust
Imperial College London
Identifier
https://www.mdpi.com/2673-4389/2/1/2
Grant Number
CF2\100002
CF2\100002
WRDH_G36066
Publication Status
Published
Date Publish Online
2022-01-15