Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
PURPOSE: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. METHODS: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. RESULTS: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97-1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95-1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95-1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81-0.99), but this association was based on a sub-analysis with a small number of cancer cases. CONCLUSIONS: In this large prospective study, coffee and tea consumptions were not associated with TC risk.
Date Issued
2018-12-10
Date Acceptance
2018-12-01
Citation
European Journal of Nutrition, 2018, 58 (8), pp.3303-3312
ISSN
0044-264X
Publisher
Springer Verlag
Start Page
3303
End Page
3312
Journal / Book Title
European Journal of Nutrition
Volume
58
Issue
8
Copyright Statement
© Springer-Verlag GmbH Germany, part of Springer Nature 2018. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs00394-018-1874-z
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30535794
PII: 10.1007/s00394-018-1874-z
Subjects
Coffee
Cohort
EPIC
Intake
Tea
Thyroid cancer
Publication Status
Published
Coverage Spatial
Germany
Date Publish Online
2018-12-10