Preparation of freeze-cast scaffolds from 58S and 13–93 sol-gel bioactive glasses for bone tissue engineering applications
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
This study investigates the fabrication of composite scaffolds using 58S and 13–93 bioactive glass particles via freeze casting followed by sintering at 650 °C. The 30/70 mass ratio of 58S/13–93 produced scaffolds with the lowest porosity (70.1 ± 2.4 %) and the highest compressive strength (11.25 ± 2.48 MPa). These scaffolds had well-ordered lamellar pores conducive to bone regeneration, as confirmed by scanning electron microscopy and X-ray microtomography. Immersion in simulated body fluid resulted in the rapid formation of carbonated hydroxyapatite, as confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive spectroscopy, which showed enhanced biological activity. The Ca/P molar ratio was similar to that of natural bone, and flow cytometry confirmed non-cytotoxicity. The combination of 58S and 13–93 bioactive glasses resulted in scaffolds with balanced mechanical and biological properties, providing an efficient and cost-effective approach for tissue engineering applications.
Date Issued
2025-02-15
Date Acceptance
2024-12-16
Citation
Materials Chemistry and Physics, 2025, 332
ISSN
0254-0584
Publisher
Elsevier BV
Start Page
130308
End Page
130308
Journal / Book Title
Materials Chemistry and Physics
Volume
332
Copyright Statement
Copyright © 2024 Elsevier B.V. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Publication Status
Published
Article Number
130308
Date Publish Online
2024-12-17