Precision medicine for pulmonary vascular disease: the future is now (2023 Grover Conference Series)
Author(s)
Type
Journal Article
Abstract
Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.
Date Issued
2025-01-01
Date Acceptance
2024-12-02
Citation
Pulmonary Circulation, 2025, 15 (1)
ISSN
2045-8940
Publisher
Wiley
Journal / Book Title
Pulmonary Circulation
Volume
15
Issue
1
Copyright Statement
© 2025 The Author(s). Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39749110
PUL270027
Subjects
biomarker
epigenetics
genomics‐metabolomics‐proteomics
pulmonary hypertension
right ventricle function and dysfunction
1102 Cardiorespiratory Medicine and Haematology
Publication Status
Published
Coverage Spatial
United States
Article Number
e70027
Date Publish Online
2025-01-02