Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
BACKGROUND: Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC. METHODS: Genotype frequencies were compared between individuals presenting with (n = 128) or without (n = 246) IM by both univariate and multivariate analysis. RESULTS: Carriers of the NQO1 609 T allele showed an association with IM in individuals who were seropositive for Helicobacter pylori (HP+; OR = 2.61, 95%CI: 1.18-5.80, P = .018). The IL-10 819 C allele was also associated with IM in HP+ individuals (OR = 2.32, 95%CI: 1.21-4.43, P = 0.011), while the PTPN11 A allele was associated with IM in HP- individuals (OR = 2.51, 95%CI: 1.16-5.40, P = 0.019), but showed an inverse association in HP+ subjects (OR = 0.46, 95%CI: 0.21-0.99, P = 0.048). CONCLUSION: Polymorphisms in NQO1, IL-10 and PTPN11, in combination with HP status, could be used to identify individuals who are more likely to develop IM and therefore GC.
Date Issued
2009-10-13
Date Acceptance
2009-10-13
Citation
BMC Gastroenterology, 2009, 9
ISSN
1471-230X
Publisher
BioMed Central
Journal / Book Title
BMC Gastroenterology
Volume
9
Copyright Statement
© Zhu et al. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Subjects
Aged
Alleles
Case-Control Studies
China
Cohort Studies
Disease Progression
Female
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-10
Intestines
Male
Metaplasia
Middle Aged
Multivariate Analysis
NAD(P)H Dehydrogenase (Quinone)
Polymorphism, Single Nucleotide
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Risk Factors
Singapore
Stomach Neoplasms
Singapore Gastric Cancer Consortium
Gastroenterology & Hepatology
1103 Clinical Sciences
Publication Status
Published
Article Number
76