Durability of immunity to SARS-CoV-2 and other respiratory viruses
Author(s)
Siggins, Matthew K
Thwaites, Ryan S
Openshaw, Peter JM
Type
Journal Article
Abstract
Even in nonpandemic times, respiratory viruses account for a vast global burden of disease. They remain a major cause of illness and death and they pose a perpetual threat of breaking out into epidemics and pandemics. Many of these respiratory viruses infect repeatedly and appear to induce only narrow transient immunity, but the situation varies from one virus to another. In the absence of effective specific treatments, understanding the role of immunity in protection, disease, and resolution is of paramount importance. These problems have been brought into sharp focus by the coronavirus disease 2019 (COVID-19) pandemic. Here, we summarise what is now known about adaptive immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and draw comparisons with immunity to other respiratory viruses, focusing on the longevity of protective responses.
Date Issued
2021-07-01
Date Acceptance
2021-04-01
Citation
Trends in Microbiology, 2021, 29 (7), pp.648-662
ISSN
0966-842X
Publisher
Cell Press
Start Page
648
End Page
662
Journal / Book Title
Trends in Microbiology
Volume
29
Issue
7
Copyright Statement
© 2021 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000659031800009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Microbiology
T-CELL RESPONSES
MEMORY B-CELLS
NEUTRALIZING ANTIBODIES
HUMAN CORONAVIRUSES
SARS CORONAVIRUS
HUMORAL IMMUNITY
DISEASE SEVERITY
PLASMA-CELLS
TIME-COURSE
INFECTION
Publication Status
Published
Date Publish Online
2021-04-08