Characterising multimorbidity from type-2 diabetes: insights from clustering approaches
File(s)
Published version
Author(s)
Cicek, Meryem
Buckley, James
Pearson-Stuttard, Jonathan
Gregg, Edward
Type
Journal Article
Abstract
Patients with type-2 diabetes mellitus (T2DM) often live with and develop multiple co-occurring conditions, namely multimorbidity, with diffuse impacts on clinical care and patient quality of life. However, literature characterising T2DM-related multimorbidity patterns is limited. This review summarises the findings from the emerging literature characterising and quantifying the association of T2DM with multimorbidity clusters. Our findings reveal three dominant cluster types appearing in patients with T2DM-related multimorbidity, such as cardiometabolic precursor conditions, vascular conditions, and mental health conditions. We recommend that holistic patient care centres around early detection of other comorbidities and consideration of wider risk factors, while future research should focus on the temporality of T2DM-related multimorbidity trajectories.
Date Issued
2021-09-01
Date Acceptance
2021-05-03
Citation
Endocrinology and Metabolism Clinics of North America, 2021, 50 (3), pp.531-558
ISSN
0889-8529
Publisher
Elsevier
Start Page
531
End Page
558
Journal / Book Title
Endocrinology and Metabolism Clinics of North America
Volume
50
Issue
3
Copyright Statement
© 2021 The Authors. Published by Elsevier Inc. This is an open access article under
the CC BY license (http://creativecommons.org/licenses/by/4.0/).
the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Medical Research Council (MRC)
Identifier
https://www.sciencedirect.com/science/article/pii/S0889852921000463?via%3Dihub
Grant Number
MR/V005057/1
Subjects
Clustering
Comorbidities
Complications
Multimorbidity
Patterns
Population health
Risk stratification
Type 2 diabetes mellitus
Endocrinology & Metabolism
1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Publication Status
Published
Date Publish Online
2021-08-13