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Hypoxia-induced pulmonary hypertension - utilising experiments of nature
File(s)
bph.15144.pdf (2.8 MB)
Published version
Author(s)
Gassmann, Max
Cowburn, Andrew
Gu, Hong
Li, Jia
Rodriguez, Marisela
Type
Journal Article
Abstract
An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest to understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature; specifically, to understand the genetic basis for the inter-individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather that cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation.
Date Issued
2021-01
Date Acceptance
2020-04-30
Citation
British Journal of Pharmacology, 2021, 178 (1), pp.121-131
URI
URL
DOI
ISSN
0007-1188
Publisher
Wiley
Start Page
121
End Page
131
Journal / Book Title
British Journal of Pharmacology
Volume
178
Issue
1
Copyright Statement
© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32464698
Subjects
High-altitude
genetics
hypoxia-inducible factor
oxygen sensing, hypoxia-inducible factor prolyl hydroxylase 2, pulmonary vasoconstriction
vascular remodelling
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-05-28