This paper presents a mechanism-based approach for modelling the thermomechanical behaviour of a Cr-Mo-V steel. A set of unified viscoplastic constitutive equations were employed to model dislocation density, recrystallisation and grain size during deformation. The evolution of dislocation density accounts for the build-up of dislocations due to plastic strain, the static and dynamic recovery and the effect of recrystallisation. Recrystallisation occurs when a critical dislocation density is reached after an incubation time, and grain size becomes smaller after such event. Gleeble compression tests were used to obtain Stress-strain curves and evaluate the microstructural evolution at different temperature and strain rate, and the material constants for the model were determined from the experimental data. Copyright © 2010 MS&T'10®.