Progress with metabolomic blood tests for gastrointestinal cancer diagnosis-an assessment of biomarker translation
File(s)
Accepted version
Author(s)
Savva, Katerina-Vanessa
Das, Bibek
Antonowicz, Stefan
Hanna, George B
Peters, Christopher J
Type
Journal Article
Abstract
There is an urgent need for cost-effective, non-invasive tools to detect early stages of gastrointestinal cancer (colorectal, gastric, and esophageal cancers). Despite many publications suggesting circulating metabolites acting as accurate cancer biomarkers, few have reached the clinic. In upper gastrointestinal cancer this is critically important, as there is no test to complement gold-standard endoscopic evaluation in patients with mild symptoms that do not meet referral criteria. Therefore, this study aimed to describe and solve this translational gap. Studies reporting diagnostic accuracy of metabolomic blood-based gastrointestinal cancer biomarkers from 2007 to 2020 were systematically reviewed and progress of each biomarker along the discovery–validation–adoption pathway was mapped. Successful biomarker translation was defined as a composite endpoint, including patent protection/FDA approval/recommendation in national guidelines. The review found 77 biomarker panels of gastrointestinal cancer, including 25 with an AUROC >0.9. All but one was stalled at the discovery phase, 9.09% were patented and none were clinically approved, confirming the extent of biomarker translational gap. In addition, there were numerous “re-discoveries,” including histidine, discovered in 7 colorectal studies. Finally, this study quantitatively supports the presence of a translational gap between discovery and clinical adoption, despite clear evidence of highly performing biomarkers with significant potential clinical value.
Date Issued
2022-12-01
Date Acceptance
2022-09-30
Citation
Cancer Epidemiology, Biomarkers and Prevention, 2022, 31 (12), pp.2095-2105
ISSN
1055-9965
Publisher
American Association for Cancer Research
Start Page
2095
End Page
2105
Journal / Book Title
Cancer Epidemiology, Biomarkers and Prevention
Volume
31
Issue
12
Copyright Statement
© 2022 American Association for Cancer Research
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000892740300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
Public, Environmental & Occupational Health
COLORECTAL-CANCER
GASTRIC-CANCER
HUMAN SERUM
POTENTIAL BIOMARKER
LIPID BIOMARKERS
ACID
METABOLITES
PLASMA
METABONOMICS
PERFORMANCE
Publication Status
Published
Date Publish Online
2022-10-10