Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer
Author(s)
Type
Journal Article
Abstract
Rhenium (I)-diselenother (Re-diselenoether) is a water soluble metal-based compound, combining one atom of rhenium and two atoms of selenium. This compound has been reported to exhibit marked activities against several solid tumor cell lines. We now disclose an improved synthesis of this complex. The Re-diselenoether showed a potent inhibitory effect on MDA-MB231 cell division in vitro, which lasted when the complex was no longer present in the culture. Re-diselenoether induced a remarkable reduction of the volume of the primitive breast tumors and of the pulmonary metastases without clinical signs of toxicity, in mice-bearing a MDA-MB231 Luc+ tumor, orthotopically transplanted, after a daily oral administration at the dose of 10 mg/kg/d. Interestingly, an antagonism was observed when cisplatin was administered as a single i.p. injection 1 week after the end of the Re-diselenoether administration. In an effort to gain insight of the mechanisms of action of Re-diselenoether complex, interaction with 9-methylguanine as a nucleic acid base model was studied. We have shown that Re-diselenoether gave both mono- and bis-guanine Re adducts, the species assumed to be responsible for the DNA intrastrand lesions.
Date Issued
2015-06-26
Date Acceptance
2015-06-17
Citation
Investigational New Drugs, 2015, 33 (4), pp.848-860
ISSN
1573-0646
Publisher
Springer Verlag (Germany)
Start Page
848
End Page
860
Journal / Book Title
Investigational New Drugs
Volume
33
Issue
4
Copyright Statement
© The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357462700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
Pharmacology & Pharmacy
Rhenium
Selenium
Breast cancer
MDA-MB231 cell line
Bioluminescence
Animals
Antineoplastic Agents
Cell Line, Tumor
Cell Survival
Coordination Complexes
Female
Guanine
Humans
Lung Neoplasms
Mammary Neoplasms, Experimental
Mice, Nude
Tissue Distribution
Tumor Burden
Oncology & Carcinogenesis
Pharmacology And Pharmaceutical Sciences
Publication Status
Published